The Daily Grind

• Refine as much Ore, Gas & Crystal (G2/G3/G4/G5) as often as possible
• Keep ample stock of Ore, Gas & Crystal of each grade for whenever the bonus refinery appears (maintain a minimum of 5m of each mineral)
  
• Refine ship parts as often as possible (ops 40+)
• Refine swarm biotics and bio minerals daily
• Refine Inert nanoprobes into activated nanoprobes (for borg officer upgrade and exchange for faction/independent credits) and charged nanoprobes (if you have not fully upgraded your vidar)
• Refine the Latinum Antique
  
• Refine the Isogens to get Iso-Emulsion and refine the Iso-Emulsion to get Iso-Resins and particles
  
• Refine Discovery Refinery Tokens
• Refine Raw Latinum/Concentrated Latinum
  

• Away assignments is an additional way to source for things required to progress
• Complete at least 1 assignment every day so you can collect traits from the dailies
  
• Level up/max as many officers as you can in order to complete these assignments successfully
• Assignments have 2 probability indicators (first for the assignment itself and second achieve critical success)
• The ensure a high chances of success the probability percentage required should be at around 90% or more for epics and rares while uncommons and commons should be around 95% or more.  These percentages are affected by the officer stats (health, attack and defense) with the indicated "Key Stat" worth double.
  
• The critical success percentage can be increased by having officers with the required traits activated.
• Complete the assignments that give star-charts otherwise you wont be able to start the rare/epic assignments as they require rare/epic star-charts to start
  
• Key assignments to focus on are those that give "Merit of Honor", latinum, minerals(ore, crystal, gas), speedups
  
• Focus the traits on specific officers that are required to increase the probabilities for critical success for the key away assignments
• Certain away assignments may not require critical success.  Examples are those that give extra star-charts for critical success.  Extra rewards can be achieved by exceeding the 100% probability for away assignment success.  The higher the percentage the higher the multiplier for these rewards.
  

• Complete all missions.  Some missions are required to access certain missions while some are required for research and others
  
• Archive missions that you cannot complete until you are able to complete them
  
• Keep missions that give resources(parsteel, tritanium, dilithium) for emergencies(e.g. your base getting drained) based on your level(No point keeping 100k rss if your needs are in billions).
  
• Keep missions that give reputation for when you need to drive up certain reputation

Please refer to "Officer Combinations" under Officers for more details on the hostile crews.
Warning:
Most players get caught up with grinding in Ty'Gokor due to the "lucrative" drops.  However, it has a big drawback.  The hostiles there cause huge increase in Federation and Romulan reputation while dropping Klingon reputation fast.  Too much of Ty and you'll find your Federation and Romulan reputation will shoot up so high you cannot complete your dailies.  Try to balance every visit to Ty'Gokor with visits to Federation and Romulan space or refrain from going there too often unless you are targeting to push up your Federation and Romulan reputation.